Peroxisomal succinyl-coenzyme a thioesterase
WebAcyl-CoA thioesterases (ACOTs) constitute a family of enzymes that hydrolyze fatty acyl-CoAs to form FFA and CoA. Although biochemically and biophysically well characterized, the metabolic functions of these enzymes remain incompletely understood. WebCatalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, …
Peroxisomal succinyl-coenzyme a thioesterase
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WebPeroxisomal acyl coenzyme A thioester hydrolase Ib . Gene name : ACOT4 Family name : C/M/P thioester hydrolase Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW WebTherefore, because succinate is found in urine and a succinyl-CoA thioesterase in peroxisomes has been identified, our data suggest that peroxisomal β-oxidation of dicarboxylic fatty acids may proceed to succinyl-CoA, followed by hydrolysis to succinate …
WebJan 22, 2013 · Peroxisomes are organelles that perform diverse metabolic functions in different organisms, but a common function is β-oxidation of a variety of long chain aliphatic, branched, and aromatic carboxylic acids. Web• To form succinyl-CoA enter the citric acid cycle. • Catalyzed by methylmalonyl-CoA mutase, • 5'-deoxyadenosylcobalamin' as coenzyme Propionic Acidemia • Propionyl-CoA carboxylase deficiency • Defects in biotin transport or ... transferred to a mitochondrion for further oxidation Peroxisomal fatty acid oxidation • The initial ...
WebAbstract. Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group-either a fatty acid or the acyl side chain of a steroid derivative-be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed.
WebPeroxisomal sorting, like the sorting into other subcellular compartments, relies on targeting signals, in this case a peroxisomal targeting signal (PTS). Ubiquitination is the attachment …
WebMar 3, 2024 · Pre-eclampsia is the most common pregnancy complication affecting 1 in 20 pregnancies, characterized by high blood pressure and signs of organ damage, most often to the liver and kidneys. Metabolic network analysis of published lipidomic data points to a shortage of Coenzyme A (CoA). Gene expression profile data reveal alterations to many … umc northwest conferenceWebMar 9, 2024 · peroxisomal succinyl-coenzyme A thioesterase, PTE-2b, acyl-coenzyme A thioesterase 4, peroxisomal acyl coenzyme A thioester hydrolase Ib, peroxisomal acyl … umc northwest districtWebPeroxisomal succinyl-coenzyme A thioesterase · Gene: ACOT4 (PTE2B, PTEIB) · Homo sapiens (Human) · EC:3.1.2.3 · 421 amino acids · Evidence at protein level · Annotation score: 5/5 # Hydrolase # Serine esterase # Fatty acid metabolism # Lipid metabolism 1 PTM 2 reviewed variants 3 active sites 1 3D structure 6 reviewed publications umcno women\u0027s healthWebAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). um coffee mugWebImportant peroxisomal enzymes include D-amino acid oxidase and catalase, the enzyme responsible for the degradation of dangerous peroxides. Peroxisomes are also involved in … thor love and thunder handshakeWebThe mouse ACOT gene cluster comprises six genes with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6). The corresponding human gene cluster contains only three genes (ACOT1, ACOT2, and ACOT4) coding for full-length thioesterase proteins only ACOT4 is peroxisomal umc northwest clinicWebWe previously identified and characterized a mouse ACOT gene cluster comprised of six genes that apparently arose by gene duplications encoding acyl-CoA thioesterases with … umc northwest texas conference