WebJan 1, 2003 · Consequently, the present study analyzes the expression of MAGE-A1, -A3, -A4, CT-7 (MAGE-C1), and NY-ESO-1 by immunohistochemistry in a panel of MMs and plasmacytomas. Results. Twenty-nine cases with histologically proven malignant gammopathies (13 myelomas, 12 medullary plasmacytomas, and 4 extramedullary … WebMay 6, 2024 · MAGE-A4, in particular, increases DNA damage tolerance and chemoresistance in a variety of cancers by stabilizing the E3-ligase RAD18 and promoting trans-lesion synthesis (TLS). Inhibition of the MAGE-A4:RAD18 axis could sensitize cancer cells to chemotherapeutics like platinating agents.
T cell receptor therapeutics hit the immuno-oncology stage - Nature
WebMay 25, 2024 · Background: MAGE-A4 is a cancer/testis antigen with expression in many solid tumors promoting cell growth by preventing cell cycle arrest and apoptosis. This study (NCT03132922) evaluated safety and efficacy of SPEAR T-cells directed against the MAGE-A4 peptide expressed in 9 tumor types. WebMay 29, 2024 · The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including #102synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by … exterior brick wall styles
MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co
WebDec 1, 2001 · Finally, MAGE-A4 was expressed in the fetal precursors of the stem germ cells from 17 weeks of gestation onward, in accordance the fact that CIS can arise from prespermatogonia in the fetus. Conclusions: MAGE-A4 can be considered a potential specific marker for normal premeiotic germ cells and germ cell tumors and can be used … WebJun 29, 2024 · The MAGE-A4 antigen was expressed in 54.9% of oesophageal cancers, 37.5% of head and neck cancers, 35.0% of gastric cancers and 34.2% of ovarian cancers; … WebDec 8, 2024 · MAGE-A4 expression IMC-C103C has a manageable safety profile and demonstrated signals of clinical activity The RECIST response rate was low in the population with zero or very low MAGE-A4... exterior brightest spot light bulbs