Crm1 and p53
WebSep 23, 2007 · To test this, we co-transfected GFP–Crm1 with Flag–WT p53 or Flag–p53EDE/A into p53 −/− MEFs. Similar levels of GFP–Crm1 and Flag–p53 were …
Crm1 and p53
Did you know?
WebSep 23, 2007 · To test this, we co-transfected GFP–Crm1 with Flag–WT p53 or Flag–p53EDE/A into p53 −/− MEFs. Similar levels of GFP–Crm1 and Flag–p53 were expressed in the transfectants . The ... WebDec 1, 2012 · These results further substantiated p53 involvement in CRM1 inhibition–mediated apoptosis and cell-cycle arrest exclusively in the wt p53 cells. Mdm2-mediated p53 ubiquitinylation exposes the latter's NES, promoting its interaction with CRM1 with a consequent enhancement of its nuclear export and cytoplasmic degradation …
WebJul 1, 2011 · In addition, p53 was found to repress Crm1 promoter activity, after induction with doxorubicin, with p53 siRNA blocking the effect. Crm1 promoter constructs with … WebAug 17, 2024 · As shown in Fig 6C, overexpression of p53 increased Gadd45a and p21 transcript levels; however, CRM1 overexpression with p53 significantly suppressed p21 and Gadd45a induction, which was …
WebCRM1 inhibition rescued p53-dependent nuclear functions and sensitized NBAT1-depleted cells to genotoxic drugs. Combined inhibition of CRM1 and MDM2 was even more … WebThe nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage The nuclear exporter protein, Crm1, plays a key role in normal cell functioning, mediating the nucleo-cytoplasmic transport of cargo proteins.
WebOct 15, 2014 · High CRM1 expression was found to be associated with lytic bone disease (P = 0.008) and shorter survival (P = 0.024). CRM1 levels are higher in bortezomib resistant MM cells. SINEs caused nuclear accumulation of multiple TSPs including p53, FOXO3a, IκB, p21 and PP2A.
WebHere, we identify the major poly (ADP-ribosyl)ated sites of p53 by PARP-1 and find that PARP-1-mediated poly (ADP-ribosyl)ation blocks the interaction between p53 and the … cara hack chip higgs dominoWebJan 4, 2024 · Subcellular distribution of p53 by the p53-responsive lncRNA NBAT1 determines chemotherapeutic response in neuroblastoma Cancer Research December 1, 2024 Neuroblastoma has a low mutation rate... broadband fibre to the premisesWebXPO1 is involved in various viral infections. For example, it is required for the nuclear export of HIV-1 RNA in complex with the viral protein Rev, an event that is a crucial part of the … broadband fibre installationWebJul 2, 2004 · This DNA damage-induced BRCA1 nuclear export utilized a CRM1-dependent mechanism and also required wild-type p53, whose function was abrogated by the E6 protein in MCF7 cells. In addition, the dependence on p53 was confirmed using a second cell type operating a tetracycline-inducible system. cara hack id higgs dominoWebCRM1, p53, and topo IIα protein expression and intracellular localization As shown by immunofluorescence microscopy, baseline CRM1 (green) nuclear localization and overall expression were high in untreated human MM cells and human MM cells treated with the inactive SINE trans-isomer KPT185T (Fig. 2 A, first column). broadband filters amazonWebAug 17, 2024 · As shown in Fig 6C, overexpression of p53 increased Gadd45a and p21 transcript levels; however, CRM1 overexpression with p53 significantly suppressed p21 and Gadd45a induction, which was mediated by p53. This result suggested that even high amounts of p53 may be ineffective at inducing p53 target genes when CRM1 is … cara hack higgs dominoWebJun 28, 2024 · Overexpression of CRM1 in cervical cancer cell lines reduced the nuclear retention of several tumor suppressors including p53, p27, p21, and p18. siRNA-induced inhibition of CRM1 in cervical cancer … broadband fibre optic deals