Cisplatin coordination complex
WebOwing to its ASNS targeting ability, complex 2-33 exhibited similar in vitro anti-tumor activity and less in vivo side toxicity relative to cisplatin by limiting the availability of asparagine. 76 ... WebStructure of cisplatin, an example of a molecule with the square planar coordination geometry. The square planar molecular geometry in chemistry describes the stereochemistry (spatial arrangement of atoms) that is adopted by certain chemical compounds. As the name suggests, molecules of this geometry have their atoms …
Cisplatin coordination complex
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WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of … WebOccasionally a 4-co-ordinated complex turns out to be square planar. There's no easy way of predicting that this is going to happen. The only one you might possibly come across at this level is cisplatin which is used …
WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. … WebSep 5, 2015 · Taken together, the complex has been shown to be a potential DNA damaging agent and, in the light of the superiority of the complex over cisplatin, we are further investigating the possibility of targeted nano-delivery of …
WebCancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the … Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells. cis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells ... Cisplatin / metabolism Cisplatin / pharmacology* Cisplatin / therapeutic use Combined Modality Therapy DNA Replication …
WebThe original: Cisplatin. Cisplatin is an example of a metal complex. The name itself is a merger of information referring to the stereoisomeric geometry adopted, cis-, and the platinum metal at the heart of the complex, -platin. Its formula is cis -PtCl 2 (NH 3) 2, with the platinum metal centre bonded to four ligands: two ammonia (NH 3) and ...
WebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … skinny fit chino pantsWebFeb 28, 2024 · It was discovered that both iodide complexes, 9a and 9b, were more effective than the chloride analogs, 10a and 10b, and cisplatin against all cisplatin-resistant cell lines; while the chloride complexes had an effect comparable to cisplatin: 11 and 11.9 μM vs. 4 μM in the A2780 cell line; 21 and 19 μM vs. 22 μM in the A2780cisR … swan motherWebStimulated by the enormous success of the inorganic complex cisplatin in tumor treatment, interest in metal complexes has recently grown. Within cells, metal complexes can participate in reactions that are not possible with conventional organic substances, and most of them have promising efficacy as anticancer drugs. swan motel beccles suffolkWebJun 19, 2024 · Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(η6-p-cymene)4Ru4(C6H2O4)2(2)2](CF3SO3)4 … skinny fit clothingCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side … See more Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some See more Cisplatin is the square planar coordination complex cis-[Pt(NH3)2Cl2]. The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic … See more Syntheses of cisplatin start from potassium tetrachloroplatinate. Several procedures are available. One obstacle is the facile formation of Magnus's green salt (MGS), which has the same empirical formula as cisplatin. The traditional way to avoid MGS involves the … See more Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical … See more Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water … See more The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's … See more Cisplatin has been studied with Auger therapy to increase the therapeutic effects of cisplatin, without increasing normal tissue toxicities. See more swan motel maryland halethorpeWebMethods: The contribution of aliphatic acyclic, aliphatic cyclic, and aromatic diamine ligands to the anticancer activity and selectivity/toxicity of metal complexes with different metal ions were analyzed by comparison with organic ligand alone and/or conventional platinum-based chemotherapeutics. swan motion sensorsWebMay 15, 2016 · Here, the available high resolution molecular structures for protein derivatives of cisplatin are systematically analyzed and discussed. In total, more than 40 distinct structures will be considered, as reported in Table 1. swan motel halethorpe md