Adipocyte to macrophage mitochondria transfer
WebDec 14, 2024 · In this report, an adipocyte-specific mitochondria reporter mouse (MitoFat) was used to establish that local macrophages acquire mitochondria from adipocytes in vivo. Interestingly, this adipocyte-to-macrophage transfer of mitochondria defined a distinct tissue macrophage subpopulation that was found to be reduced in obesity. WebSep 1, 2024 · In obesity, adipocyte-to-macrophage mitochondria transfer is impaired, and instead, adipocytes release mitochondria into the blood to induce a protective …
Adipocyte to macrophage mitochondria transfer
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WebObesity leads to the recruitment by adipocytes of macrophages. These macrophages are activated to produce inflammatory cytokines, which blunt insulin signaling. ... such as the PPARγ agonists, induce a host of mitochondrial proteins and improve mitochondrial function in adipocytes . Impaired mitochondrial respiratory function triggers a ... WebDec 29, 2024 · In this report, an adipocyte-specific mitochondria reporter mouse (MitoFat) was used to establish that local macrophages acquire mitochondria from adipocytes …
WebOct 22, 2024 · White adipose tissue (WAT) macrophages exhibit lower HS levels, resulting in reduced intercellular mitochondrial transfer from adipocytes to macrophages in mice with obesity or deletion of the myeloid-cell HS biosynthesis gene exostosin-1 (Ext1), which increases body weight and obesity and decreases glucose tolerance and insulin … WebApr 3, 2024 · In high-fat condition, macrophages form the crown-like structure, which surrounds adipocytes. Macrophages phagocyte dead cells and debris. A high-fat diet also induces the proliferation of pre-adipocytes through the activation of the Id3 factor and activates the synthesis of MCP-1. ... Transfer of mitochondria between macrophages …
WebFeb 16, 2024 · During resolution of inflammatory pain in mice, M2-like macrophages infiltrate the dorsal root ganglia that contain the somata of sensory neurons, concurrent with the recovery of oxidative phosphorylation in sensory neurons. The resolution of pain and the transfer of mitochondria requires expression of CD200 receptor (CD200R) on … WebApr 22, 2024 · Adipocytes and macrophages interact with each other through a variety of mechanisms, including cytokine and chemokines, microRNA-containing exosomes or …
WebWe found that adipocyte-to-macrophage mitochondria transfer in white adipose tissue is inhibited in murine obesity elicited by a lard-based high-fat diet, but not a hydrogenated-coconut-oil-based high-fat diet, aging, or a corn-starch diet.
WebFeb 3, 2024 · Monocyte/macrophage cytokine production is heightened after uremia exposure. Since uremia alters adipose tissue cytokine production and increases ATMS infiltration 14, we studied the effects of ... cultural access pass calgaryeast lake house birmingham alWebMar 1, 2024 · Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Brestoff JR , Wilen CB , Moley JR , Li Y , Zou W , Malvin NP , Rowen MN , Saunders BT , Ma H , Mack MR , Hykes BL Jr , Balce DR , Orvedahl A , Williams JW , Rohatgi N , Wang X , McAllaster MR , Handley … cultural academy for the arts \u0026 sciencesWebApr 12, 2024 · Macrophage-mediated inflammation has been ... cells displaying fewer than 200 gene features or having more than 5% mitochondrial counts were filtered. After passing the quality control metrics, 5914 cells in the Sham group, 6975 cells in the HLI group, 7064 cells in the HLI (tdT cells) group, and 7319 cells in the HLI + BM (tdT cells) … eastlakelibrary.org/passportsWebOct 18, 2024 · Analysis of mice expressing an adipocyte-specific mitochondrial reporter revealed that mitochondria were transferred not only to macrophages but also to … eastlake lake park in chula vista caWebOct 13, 2024 · Macrophages in white adipose tissue regulate lipid metabolism and insulin sensitivity in adipocytes via paracrine effects of noradrenalin. VE, vascular endothelial. … cultural accommodation hypothesisWebApr 5, 2024 · Although the mitochondria of brown adipocytes comprise a large component of the cell volume and undergo reorganization to sustain thermogenesis, it remains unclear whether an intercellular mitochondrial transfer occurs in brown adipose tissue (BAT) and regulates adaptive thermogenesis. east lake macquarie anglican church